In Vitro Evaluation of Portuguese Propolis and Floral Sources for Antiprotozoal, Antibacterial and Antifungal Activity
Identifieur interne : 001062 ( Main/Exploration ); précédent : 001061; suivant : 001063In Vitro Evaluation of Portuguese Propolis and Floral Sources for Antiprotozoal, Antibacterial and Antifungal Activity
Auteurs : Soraia I. Falcão [Portugal] ; Nuno Vale [Portugal] ; Paul Cos [Belgique] ; Paula Gomes [Portugal] ; Cristina Freire [Portugal] ; Louis Maes [Belgique] ; Miguel Vilas-Boas [Portugal]Source :
- Phytotherapy Research [ 0951-418X ] ; 2014-03.
Abstract
Propolis is a beehive product with a very complex chemical composition, used since ancient times in several therapeutic treatments. As a contribution to the improvement of drugs against several tropical diseases caused by protozoa, we screened Portuguese propolis and its potential floral sources Populus x Canadensis and Cistus ladanifer against Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei and Trypanosoma cruzi. The toxicity against MRC‐5 fibroblast cells was evaluated to assess selectivity. The in vitro assays were performed following the recommendations of WHO Special Programme for Research and Training in Tropical Diseases (TDR) and revealed moderate activity, with the propolis extracts presenting the relatively highest inhibitory effect against T. brucei. Additionally, the antimicrobial activity against Staphylococcus aureus, Candida albicans, Trichophyton rubrum and Aspergillus fumigatus was also verified with the better results observed against T. rubrum. The quality of the extracts was controlled by evaluating the phenolic content and antioxidant activity. The observed biological activity variations are associated with the variable chemical composition of the propolis and the potential floral sources under study. Copyright © 2013 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/ptr.5013
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001461
- to stream Istex, to step Curation: 001461
- to stream Istex, to step Checkpoint: 000155
- to stream Main, to step Merge: 001063
- to stream Main, to step Curation: 001062
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">In Vitro Evaluation of Portuguese Propolis and Floral Sources for Antiprotozoal, Antibacterial and Antifungal Activity</title><author><name sortKey="Falcao, Soraia I" sort="Falcao, Soraia I" uniqKey="Falcao S" first="Soraia I." last="Falcão">Soraia I. Falcão</name></author><author><name sortKey="Vale, Nuno" sort="Vale, Nuno" uniqKey="Vale N" first="Nuno" last="Vale">Nuno Vale</name></author><author><name sortKey="Cos, Paul" sort="Cos, Paul" uniqKey="Cos P" first="Paul" last="Cos">Paul Cos</name></author><author><name sortKey="Gomes, Paula" sort="Gomes, Paula" uniqKey="Gomes P" first="Paula" last="Gomes">Paula Gomes</name></author><author><name sortKey="Freire, Cristina" sort="Freire, Cristina" uniqKey="Freire C" first="Cristina" last="Freire">Cristina Freire</name></author><author><name sortKey="Maes, Louis" sort="Maes, Louis" uniqKey="Maes L" first="Louis" last="Maes">Louis Maes</name></author><author><name sortKey="Vilas Oas, Miguel" sort="Vilas Oas, Miguel" uniqKey="Vilas Oas M" first="Miguel" last="Vilas-Boas">Miguel Vilas-Boas</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:0A0B768D659D8A39A6C023322570863D66F1DC14</idno><date when="2014" year="2014">2014</date><idno type="doi">10.1002/ptr.5013</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-J846M98C-5/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001461</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001461</idno><idno type="wicri:Area/Istex/Curation">001461</idno><idno type="wicri:Area/Istex/Checkpoint">000155</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000155</idno><idno type="wicri:doubleKey">0951-418X:2014:Falcao S:in:vitro:evaluation</idno><idno type="wicri:Area/Main/Merge">001063</idno><idno type="wicri:Area/Main/Curation">001062</idno><idno type="wicri:Area/Main/Exploration">001062</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">In Vitro Evaluation of Portuguese Propolis and Floral Sources for Antiprotozoal, Antibacterial and Antifungal Activity</title><author><name sortKey="Falcao, Soraia I" sort="Falcao, Soraia I" uniqKey="Falcao S" first="Soraia I." last="Falcão">Soraia I. Falcão</name><affiliation wicri:level="1"><country xml:lang="fr">Portugal</country><wicri:regionArea>CIMO ‐ Escola Superior Agrária, Instituto Politécnico de Bragança, Campus de Sta. Apolónia, Apartado 1172, 5301‐855, Bragança</wicri:regionArea><wicri:noRegion>Bragança</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Portugal</country><wicri:regionArea>REQUIMTE ‐ Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, 687, 4169‐007, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Vale, Nuno" sort="Vale, Nuno" uniqKey="Vale N" first="Nuno" last="Vale">Nuno Vale</name><affiliation wicri:level="1"><country xml:lang="fr">Portugal</country><wicri:regionArea>CIQ‐UP, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, 687, 4169‐007, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Cos, Paul" sort="Cos, Paul" uniqKey="Cos P" first="Paul" last="Cos">Paul Cos</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, B‐2610, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Gomes, Paula" sort="Gomes, Paula" uniqKey="Gomes P" first="Paula" last="Gomes">Paula Gomes</name><affiliation wicri:level="1"><country xml:lang="fr">Portugal</country><wicri:regionArea>CIQ‐UP, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, 687, 4169‐007, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Freire, Cristina" sort="Freire, Cristina" uniqKey="Freire C" first="Cristina" last="Freire">Cristina Freire</name><affiliation wicri:level="1"><country xml:lang="fr">Portugal</country><wicri:regionArea>REQUIMTE ‐ Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, 687, 4169‐007, Porto</wicri:regionArea><wicri:noRegion>Porto</wicri:noRegion></affiliation></author><author><name sortKey="Maes, Louis" sort="Maes, Louis" uniqKey="Maes L" first="Louis" last="Maes">Louis Maes</name><affiliation wicri:level="4"><country xml:lang="fr">Belgique</country><wicri:regionArea>Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, B‐2610, Antwerp</wicri:regionArea><orgName type="university">Université d'Anvers</orgName><placeName><settlement type="city">Anvers</settlement><region>Région flamande</region><region type="district" nuts="2">Province d'Anvers</region></placeName></affiliation></author><author><name sortKey="Vilas Oas, Miguel" sort="Vilas Oas, Miguel" uniqKey="Vilas Oas M" first="Miguel" last="Vilas-Boas">Miguel Vilas-Boas</name><affiliation wicri:level="1"><country xml:lang="fr">Portugal</country><wicri:regionArea>CIMO ‐ Escola Superior Agrária, Instituto Politécnico de Bragança, Campus de Sta. Apolónia, Apartado 1172, 5301‐855, Bragança</wicri:regionArea><wicri:noRegion>Bragança</wicri:noRegion></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Portugal</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Phytotherapy Research</title><title level="j" type="alt">PHYTOTHERAPY RESEARCH</title><idno type="ISSN">0951-418X</idno><idno type="eISSN">1099-1573</idno><imprint><biblScope unit="vol">28</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="437">437</biblScope><biblScope unit="page" to="443">443</biblScope><biblScope unit="page-count">7</biblScope><date type="published" when="2014-03">2014-03</date></imprint><idno type="ISSN">0951-418X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0951-418X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Propolis is a beehive product with a very complex chemical composition, used since ancient times in several therapeutic treatments. As a contribution to the improvement of drugs against several tropical diseases caused by protozoa, we screened Portuguese propolis and its potential floral sources Populus x Canadensis and Cistus ladanifer against Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei and Trypanosoma cruzi. The toxicity against MRC‐5 fibroblast cells was evaluated to assess selectivity. The in vitro assays were performed following the recommendations of WHO Special Programme for Research and Training in Tropical Diseases (TDR) and revealed moderate activity, with the propolis extracts presenting the relatively highest inhibitory effect against T. brucei. Additionally, the antimicrobial activity against Staphylococcus aureus, Candida albicans, Trichophyton rubrum and Aspergillus fumigatus was also verified with the better results observed against T. rubrum. The quality of the extracts was controlled by evaluating the phenolic content and antioxidant activity. The observed biological activity variations are associated with the variable chemical composition of the propolis and the potential floral sources under study. Copyright © 2013 John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>Portugal</li></country><region><li>Province d'Anvers</li><li>Région flamande</li></region><settlement><li>Anvers</li></settlement><orgName><li>Université d'Anvers</li></orgName></list><tree><country name="Portugal"><noRegion><name sortKey="Falcao, Soraia I" sort="Falcao, Soraia I" uniqKey="Falcao S" first="Soraia I." last="Falcão">Soraia I. Falcão</name></noRegion><name sortKey="Falcao, Soraia I" sort="Falcao, Soraia I" uniqKey="Falcao S" first="Soraia I." last="Falcão">Soraia I. Falcão</name><name sortKey="Freire, Cristina" sort="Freire, Cristina" uniqKey="Freire C" first="Cristina" last="Freire">Cristina Freire</name><name sortKey="Gomes, Paula" sort="Gomes, Paula" uniqKey="Gomes P" first="Paula" last="Gomes">Paula Gomes</name><name sortKey="Vale, Nuno" sort="Vale, Nuno" uniqKey="Vale N" first="Nuno" last="Vale">Nuno Vale</name><name sortKey="Vilas Oas, Miguel" sort="Vilas Oas, Miguel" uniqKey="Vilas Oas M" first="Miguel" last="Vilas-Boas">Miguel Vilas-Boas</name><name sortKey="Vilas Oas, Miguel" sort="Vilas Oas, Miguel" uniqKey="Vilas Oas M" first="Miguel" last="Vilas-Boas">Miguel Vilas-Boas</name></country><country name="Belgique"><region name="Région flamande"><name sortKey="Cos, Paul" sort="Cos, Paul" uniqKey="Cos P" first="Paul" last="Cos">Paul Cos</name></region><name sortKey="Maes, Louis" sort="Maes, Louis" uniqKey="Maes L" first="Louis" last="Maes">Louis Maes</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001062 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001062 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:0A0B768D659D8A39A6C023322570863D66F1DC14
|texte= In Vitro Evaluation of Portuguese Propolis and Floral Sources for Antiprotozoal, Antibacterial and Antifungal Activity
}}
| This area was generated with Dilib version V0.6.33. |  |